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Bioactivities and Cytotoxicities Effects of 3′,4′-Dihydroxy-7-Methoxyflavone and 2′-Hydroxy-3,4,3′,4′-Tetramethoxychalcone

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Synthetic compounds 3′,4′-dihydroxy-7-methoxyflavone (DHMF) and 2′-hydroxy-3,4,3′,4′-tetramethoxychalcone (HTMC) were investigated for their antioxidant and anti-tyrosinase activities. Antioxidant activities were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and Ferric Reducing Ability of Plasma (FRAP) assay. DHMF possessed antioxidant activities with no activity detected for HTMC. Further investigation demonstrates that DHMF possessed greater antioxidant capacity at longer incubation time compared to L-ascorbic acid. In contrast, HTMC demonstrates a novel anti-tyrosinase activity with no activity observed for DHMF. Evaluation on cytotoxicity effects revealed that both synthetic compounds inhibit the viability of CHO and HeLa cells in a concentration-dependent manner with no effect detected at low concentration.
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Document Type: Research Article

Publication date: December 1, 2013

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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