An Investigation of the Anti-Inflammatory Potential of Silk Sericin
Silk sericin was found to suppress the production of pro-inflammatory cytokines which are related to the inflammatory reaction. The objectives of this study were to investigate the anti-inflammatory effect of sericin in vivo using carrageenan-induced rat edema model and changes in the histology of tissues. The effects of a sericin on the expression of COX-2 and iNOS were also evaluated. Sericin solutions at 0.004–0.080 mg/mL were applied topically to the top of the hind paw and carrageenan (1.0 mg) was injected subcutaneously to the plantar surface of the right hind paw. Our results indicated that sericin significantly reduced the inflammation in rats' paw compared to negative control (water and acetone) and its effect at 0.080 mg/mL was only slightly lower than of 1.0% w/v indomethacin. Similar numbers of polymorphonuclear and macrophage cells were found in rats' tissue treated with indomethacin and sericin solution while the numbers were significantly higher in their absence. The gene expression results by RT-PCR showed that the COX-2 and iNOS genes were down-regulated in samples treated with sericin in dose dependent manner. This data indicated that the anti-inflammatory properties of sericin may be partly attributable to the suppression of the COX-2 enzyme and nitric oxide production.
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Document Type: Research Article
Publication date: December 1, 2013
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