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Synthesis of L-Cysteine Stabilized Silver Nanoparticles and Their Effects on Cell Viability

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The aim of this study was to synthesize L-cysteine stabilized silver nanoparticles of 2 nm in size and determine their impact on cell viability. Silver particles of this size range stabilized with L-cysteine woule be novel, as a similar study by Mandal et al. on cysteine capped silver nanoparticles achieved particles of only 4.4±0.3 nm. Currently, methods to synthesize and separate 2 nm silver particles effectively are limited. Silver nanoparticles are an ideal candidate for biological applications due to its natural anti-bacterial, anti-inflammatory, and anti-platelet properties. For the 1st time, L-cysteine capped silver nanoparticles 2±1 nm in diameter were synthesized and successfully separated that also showed a non-significant impact on MCDK cell viability. Synthesis of the silver nanoparticles was achieved via a reduction of AgNO3 and NaBH4. Capping was achieved via a thiolate linkage between the amino acid and the silver particles upon addition of L-cysteine to the colloid solution. Particles were stable for up to 24 hours after which aggregates can be detected. Cell viability was determined via a trypan blue stain for dead cells, and showed comparable levels of cell death between control and nanoparticle treated cells. This study adds further evidence to the role that particle size and surface charge play in overall cell viability from silver nanoparticles. These characteristics can lead to the design of silver nanoparticles that maintain clinical functionality while minimizing toxic effects.
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Document Type: Research Article

Publication date: March 1, 2012

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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