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Full Adder and Full Subtractor Operations by DNA Self-Assembly

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Due to optical wavelength limitations in conventional lithographic fabrication techniques and physical limits, silicon-based technology improvements will soon begin to approach their ultimate limits. Self-assembly is one of the most prospective methods to overcome the contact problem, and became one of the most important directions of molecular electronics development. In this paper, three kinds of stable DNA tiles including the x tiles, y tiles and initialization corner c tiles are constructed to execute the full adder and full subtractor operations with three oligonucleotides as inputs and two independent fluorogenic cleavage reactions as outputs. This work indicates that the realization of the full adder and full subtractor using DNA self-assembly are carried with parallel logic gates operations. The method that we discuss here are fundamental to the logical operations, but it seems possible to further extend more complex logic circuits using a molecular computer by self-assembly.
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Document Type: Research Article

Publication date: February 1, 2011

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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