Evaluation of the Physicochemical Characteristics of Liposomal Formulations of Doctor's Formulas' Food Supplements
Food supplements are considered as complementary supporters and supplement the human health and nutrient, respectively. They are used in cases that essential elements are missing from the human organism because of the modern lifestyle. Nanotechnology involves the utilization of nanoparticulate sytems such as liposomes in order to physicochemically protect, stabilize and safely transport food supplements like minerals, vitamins, antioxidants as well as bioactive materials to the tissues by increasing their absorption and bioavailability. The purpose of this investigation is to study the physicochemical characteristics of nanoparticulate/liposomal formulations incorporating vitamins and food supplements based on liposomal technology. Dynamic and Electrophoretic Light Scattering Techniques (DLS and ELS) were used in order to determine the size distribution and the zeta potential of the colloidal particles of these formulations. Contin and NNLS which are the distribution algorithms in the DLS were used in order to evaluate the size and the size distribution of the final formulations. The studies revealed that the colloidal particles are in the nanoscale dimension and could be characterized as multilamellar vesicles with adequate size and size distribution with respect to the nature of the product particles. The liposomal products are not considered "nanotechnology"-based formulations by regulations but are often categorized as such by literature. The positive ζ-potential of the particles justifies sufficiently the physicochemical stability of the final food supplement liposomal formulation. Based on the founding's from the analysis of the liposomal platforms incorporating vitamins and food supplements, prove the quality of the products of Doctor's Formulas. Finally, the existence of multilammellar vesicles i.e., liposomes supports the reliance on the successful delivery of food supplements in the target cells with higher bioavailability.
Keywords: COLLOIDAL STABILITY; FOOD SUPPLEMENTS; LIPOSOMES; MULTILAMELLAR VESICLES; SIZE; STABILITY; ζ-POTENTIAL
Document Type: Research Article
Publication date: February 1, 2017
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