Hematopoietic and Antioxidant Activities of Gold Nanoparticles Synthesized by Aqueous Extract of Fenugreek (Trigonella foenum-graecum) Seed
Fenugreek (Trigonella foenum-graecum) seed has been used for long time as a hematopoietic and antioxidant agent in traditional therapeutics. In the present study, aqueous fenugreek seed extract (FSE) was used to synthesize gold nanoparticle (FG-GNP) and its physico-chemical characteristics were carried out by UV-Vis spectra, fluorescent activity, dynamic light scattering and transmission electron microscopy. UV-Vis spectra showed the maximum absorbance of GNP at 535 nm. It showed fluorescence quenching activity when compared with FSE. Its hydrodynamic diameter was 170.6 nm with poly-dispersity index 0.286. Transmission electron microscopy showed that the shape of GNP was nearly spherical with 5–20 nm size. Hematopoietic and antioxidant properties of GNP were studied in experimental anemic Swiss male albino mice. Anemia was induced in animals by blood loss at regular interval. FG-GNP treatment significantly increased blood hemoglobin, total count of RBC, hematocrit value, serum iron concentration and decreased total iron binding capacity in experimental anemic mice. Treatment with FG-GNP increased the antioxidant parameters such as superoxide dismutase, catalase and reduced glutathione activity significantly (P < 0.05) and caused no change in lipid peroxidation. Further studies regarding molecular effects of FG-GNP are warranted.
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Document Type: Research Article
Publication date: May 1, 2014
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