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Application of N-Bromosuccinimide in the Quantitative Analysis of N-Acetyl L-Cysteine in Pharmaceutical Dosage Forms

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An analytical method has been developed for the determination of N-acetyl L cysteine in pure and pharmaceutical preparations using spectrophotometry. In the current method the oxidizing property of N-Bromosuccinimide has been exploited and made to react with N-acetyl cysteine, thus the oxidation of n-acetyl l-cysteine by N-Bromosuccinimide (NBS) was made the basis of the current method development. The oxidation product absorbs maximally as 352 nm and the drug obeyed the beer's law in the concentration range of 2–44 μg ml–1. The mass spectrometric treatment of the oxidation product showed that the product formed due to the oxidation of drug with NBS resulted in the formation of sulphonic acid derivative of N-acetyl—cysteine. The statistical treatment of data was performed and the limits of detection (LOD) and limits of detection quantitation (LOQ) for the proposed method are 0.572 and 1.732 μg ml–1, respectively. The proposed procedure has been successfully applied for the determination of N-acetyl L-cysteine in pharmaceutical formulations. The results obtained by the proposed method were statistically compared with the reference method using t and F values and found that there is no major difference between the two methods.
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Keywords: N-ACETYL L-CYSTEINE; N-BROMOSUCCINIMIDE; OXIDATION; SPECTROPHOTOMETRY

Document Type: Research Article

Publication date: June 1, 2013

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  • Advanced Chemistry Letters is an international multidisciplinary peer-reviewed journal covering all fundamental and applied research areas of chemical sciences including organic chemistry, inorganic chemistry, synthetic chemistry, medicinal chemistry, analytical chemistry, organometallic chemistry, nuclear chemistry, electrochemistry, atmospheric chemistry, environmental chemistry, materials chemistry, materials science, supramolecular chemistry, physical chemistry, polymer chemistry, bioinorganic chemistry, physical organic chemistry, surface chemistry, biochemistry, molecular biology, chemical biology, food chemistry, natural product chemistry, neurochemistry, pharmacology, photochemistry, photobiology, toxicology, nanoscience, nanotechnology, agrochemistry, green chemistry, marine chemistry, geochemistry, petrochemistry, radiochemistry, astrochemistry, molecular physics, chemical engineering, quantum chemistry, and theoretical and computational chemistry.
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