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Synthesis, Characterization and Anti Microbial Activity of Some Heterocyclic Ketone Thiosemicarbazones

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A series of 5-substituted-2-(acetamido)-4-acetyl-Δ2-1,3,4-thiadiazolines were synthesized by the cyclization of aliphatic ketone thiosemicarbazones using acetic anhydride. The synthesized compounds were characterized based on their elemental composition and analyzing their vibrational spectra in comparison with theoretically predicted spectrum to understand their structure and potential for antimicrobial activity. A comparative study of their antimicrobial and antifungal susceptibility against selected micro organisms (bacteria such as Bacillus subtillis, Proteus mirabilis, Klebsiella pneumonia and Staphylococcus aureuws and fungi such as Trichophyton Verrucosum, Trichophyton rubrum and Trichophyton mentagrophytes) illustrate that these compounds possess good antibacterial activities rather than antifungal activities.
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Keywords: ANTI-FUNGAL ACTIVITY; ANTI-MICROBIAL ACTIVITY; IR SPECTRUM; SYNTHESIS; THIADIAZOLINES; VIBRATIONS

Document Type: Research Article

Publication date: June 1, 2013

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  • Advanced Chemistry Letters is an international multidisciplinary peer-reviewed journal covering all fundamental and applied research areas of chemical sciences including organic chemistry, inorganic chemistry, synthetic chemistry, medicinal chemistry, analytical chemistry, organometallic chemistry, nuclear chemistry, electrochemistry, atmospheric chemistry, environmental chemistry, materials chemistry, materials science, supramolecular chemistry, physical chemistry, polymer chemistry, bioinorganic chemistry, physical organic chemistry, surface chemistry, biochemistry, molecular biology, chemical biology, food chemistry, natural product chemistry, neurochemistry, pharmacology, photochemistry, photobiology, toxicology, nanoscience, nanotechnology, agrochemistry, green chemistry, marine chemistry, geochemistry, petrochemistry, radiochemistry, astrochemistry, molecular physics, chemical engineering, quantum chemistry, and theoretical and computational chemistry.
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