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Gene Delivery Using Cationic Micelles and Vesicles

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Over the past few decades, the discovery and development of recombinant DNA technology and sequencing of the human genome have opened the possibility to battle numerous diseases at the genetic level. These achievements have advanced the development of the scientific field of gene therapy, which has been acknowledged for its high potential and has gained interest ever since. However, due to the scarcity of clinically relevant results, the enthusiasm has been tempered the last few years. Currently the success of gene therapy and the therapeutic use of RNA interference (RNAi) rely on the efficient, safe and specific cellular delivery of nucleic acids. Despite extensive efforts, several obstacles impede successful application of viral and non-viral delivery strategies. The aim of the study described in this paper is to present gene delivery device for nucleic acids, based on cationic micelles and vesicles that combine the delivery efficiency of the viral vectors and the safety of the non-viral systems.
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Document Type: Review Article

Publication date: June 1, 2013

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  • Advanced Chemistry Letters is an international multidisciplinary peer-reviewed journal covering all fundamental and applied research areas of chemical sciences including organic chemistry, inorganic chemistry, synthetic chemistry, medicinal chemistry, analytical chemistry, organometallic chemistry, nuclear chemistry, electrochemistry, atmospheric chemistry, environmental chemistry, materials chemistry, materials science, supramolecular chemistry, physical chemistry, polymer chemistry, bioinorganic chemistry, physical organic chemistry, surface chemistry, biochemistry, molecular biology, chemical biology, food chemistry, natural product chemistry, neurochemistry, pharmacology, photochemistry, photobiology, toxicology, nanoscience, nanotechnology, agrochemistry, green chemistry, marine chemistry, geochemistry, petrochemistry, radiochemistry, astrochemistry, molecular physics, chemical engineering, quantum chemistry, and theoretical and computational chemistry.
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