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Dynamic Rabbit Model of Ear Barotrauma

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BACKGROUND: Establishing animal models of ear barotrauma (EB) to provide evaluation criteria for Eustachian tube dysfunction.

METHODS: Using expansive sponges, 70 rabbits’ right pharyngeal openings of the auditory tubes were blocked to cause dysfunction in the right Eustachian tubes. The right tympanic cavities of 65 rabbits were the Model Group (Subgroups 1–13) and these rabbits’ left tympanic cavities were the Nonblockage Group. Hypobaric chamber tests (HCTs) at various vertical speeds (100 m · s−1, 75 m · s−1, 50 m · s−1, and 15 m · s−1) and altitudes (13,123 ft and 6562 ft) were conducted. The remaining five rabbits’ right tympanic cavities were the Control Group and no HCTs were conducted. After HCTs, observations were made on rabbits’ behavioral changes, oto-endoscope and tympanometry results, and pathological changes of the tympanic mucosae.

RESULTS: 1) Rabbits in Subgroups 1–12 demonstrated EB, while Subgroup 13 and the Control Group did not. 2) Histopathology showed EB caused by rapid ascent/descent at 100 m · s−1 was more severe than that of 75 m · s−1 and 50 m · s−1 (P < 0.01), and that there were no significant differences in EB caused by rapid ascent/descent at 75 m · s−1 and 50 m · s−1 (P > 0.05). There were no significant differences in pathological injuries at the altitudes of 6562 ft and 13,123 ft (P > 0.05). 3) Based on tympanic membrane structures, tympanometry, and histopathological results, rabbits’ EB can be classified into mild, moderate, and severe.

DISCUSSION: EB’s dynamic models could be established through HCTs on rabbits with Eustachian tube dysfunction.

Wang B, Xu X, Lin J, Jin Z. Dynamic rabbit model of ear barotrauma. Aerosp Med Hum Perform. 2019; 90(8):696–702.
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Keywords: Eustachian tube dysfunction; animals; disease models; ear barotrauma; hypobaric chamber tests

Document Type: Research Article

Publication date: August 1, 2019

More about this publication?
  • This journal (formerly Aviation, Space, and Environmental Medicine), representing the members of the Aerospace Medical Association, is published monthly for those interested in aerospace medicine and human performance. It is devoted to serving and supporting all who explore, travel, work, or live in hazardous environments ranging from beneath the sea to the outermost reaches of space. The original scientific articles in this journal provide the latest available information on investigations into such areas as changes in ambient pressure, motion sickness, increased or decreased gravitational forces, thermal stresses, vision, fatigue, circadian rhythms, psychological stress, artificial environments, predictors of success, health maintenance, human factors engineering, clinical care, and others. This journal also publishes notes on scientific news and technical items of interest to the general reader, and provides teaching material and reviews for health care professionals.

    To access volumes 74 through 85, please click here.
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