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Construction of Measurement Uncertainty Profiles for Quantitative Analysis of Genetically Modified Organisms Based on Interlaboratory Validation Data

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A method is presented for estimating the size of uncertainty associated with the measurement of products derived from genetically modified organisms (GMOs). The method is based on the uncertainty profile, which is an extension, for the estimation of uncertainty, of a recent graphical statistical tool called an accuracy profile that was developed for the validation of quantitative analytical methods. The application of uncertainty profiles as an aid to decision making and assessment of fitness for purpose is also presented. Results of the measurement of the quantity of GMOs in flour by PCR-based methods collected through a number of interlaboratory studies followed the log-normal distribution. Uncertainty profiles built using the results generally give an expected range for measurement results of 50200 of reference concentrations for materials that contain at least 1 GMO. This range is consistent with European Network of GM Laboratories and the European Union (EU) Community Reference Laboratory validation criteria and can be used as a fitness for purpose criterion for measurement methods. The effect on the enforcement of EU labeling regulations is that, in general, an individual analytical result needs to be <0.45 to demonstrate compliance, and >1.8 to demonstrate noncompliance with a labeling threshold of 0.9.
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Document Type: Research Article

Affiliations: 1: Food and Environment Research Agency, Risk and Numerical Sciences Team, Sand Hutton, YO41 1LZ York, United Kingdom. 2: Institut National de la Recherche Agronomique, Metrisk, 16 rue Claude Bernard, 75231 Paris Cedex 05, France. 3: Institut National de la Recherche Agronomique, Phytopathologie et Mthodologies de la Dtection, Route de Saint Cyr, 78026 Versailles Cedex, France.

Publication date: May 1, 2010

More about this publication?
  • The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents.
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