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Evaluating the Performance of Sampling Plans to Detect Hypoglycin A in Ackee Fruit Shipments Imported into the United States

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Hypoglycin A (HGA) is a toxic amino acid that is naturally produced in unripe ackee fruit. In 1973, the U.S. Food and Drug Administration (FDA) placed a worldwide import alert on ackee fruit, which banned the product from entering the United States. The FDA has considered establishing a regulatory limit for HGA and lifting the ban, which will require development of a monitoring program. The establishment of a regulatory limit for HGA requires the development of a scientifically based sampling plan to detect HGA in ackee fruit imported into the United States. Thirty-three lots of ackee fruit were sampled according to an experimental protocol in which 10 samples, i.e., ten 19 oz cans, were randomly taken from each lot and analyzed for HGA by using liquid chromatography. The total variance was partitioned into sampling and analytical variance components, which were found to be a function of the HGA concentration. Regression equations were developed to predict the total, sampling, and analytical variances as a function of HGA concentration. The observed HGA distribution among the test results for the 10 HGA samples was compared with the normal and lognormal distributions. A computer model based on the lognormal distribution was developed to predict the performance of sampling plan designs to detect HGA in ackee fruit shipments. The performance of several sampling plan designs was evaluated to demonstrate how to manipulate sample size and accept/reject limits to reduce misclassification of ackee fruit lots.
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Document Type: Research Article

Affiliations: 1: U.S. Department of Agriculture, Agricultural Research Service, Box 7625, North Carolina State University, Raleigh, NC 27695-7625. 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Safety, 5100 Paint Branch Pkwy, College Park, MD 20740-3835. 3: U.S. Food and Drug Administration, 60 8th St, NE, Atlanta, GA 30309. 4: North Carolina State University, Biological and Agricultural Engineering Department, Box 7625, Raleigh, NC 27695-7625.

Publication date: July 1, 2007

More about this publication?
  • The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents.
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