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Determination of Caffeine and Caffeine-Related Metabolites in Ephedra-Containing Standard Reference Materials Using Liquid Chromatography with Absorbance Detection and Tandem Mass Spectrometry

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The concentrations of caffeine and caffeine-related compounds in 2 ephedra-containing reference materials have been determined by 3 independent methods with measurements performed by the National Institute of Standards and Technology (NIST) and a collaborating laboratory. Results from the 3 methods were used for value assignment of caffeine, theobromine, and theophylline in these Standard Reference Materials (SRMs). The methods used at NIST to determine the concentration levels of caffeine, theobromine, and theophylline in SRM 3243 Ephedra-Containing Solid Oral Dosage Form and SRM 3244 Ephedra-Containing Protein Powder used reversed-phase liquid chromatography with absorbance detection and tandem mass spectrometry. These reference materials are part of the first suite in a series of NIST SRMs that provide concentration values for multiple components in dietary supplements. These SRMs are primarily intended for method validation and for use as control materials to support the analysis of dietary supplements and similar materials.
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Document Type: Research Article

Affiliations: 1: National Institute of Standards and Technology, Analytical Chemistry Division, Gaithersburg, MD 20899-8392. 2: K-Force, 1001 East Palm Ave, Tampa, FL 33605; ChromaDex, Inc., Clearwater, FL 33760. 3: Tampa Bay Analytical Research, Inc., 10810 72nd St, Suite 206, Largo, FL 33777; ChromaDex, Inc., Clearwater, FL 33760. 4: National Institute of Standards and Technology, Statistical Engineering Division, Gaithersburg, MD 20899-8980. 5: National Institute of Standards and Technology, Biochemical Science Division, Gaithersburg, MD 20899-8392.

Publication date: July 1, 2007

More about this publication?
  • The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents.
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