Skip to main content
padlock icon - secure page this page is secure

Development and Characterization of Naproxen-Loaded Poly(vinyl alcohol) Nanofibers Crosslinked with Polycarboxylic Acids

Buy Article:

$35.00 + tax (Refund Policy)

Poly(vinyl alcohol) (PVA) hydrogel nanofibers are a potential candidate for textile-based drug-release applications. Polycarboxylic acids 1,2,3,4-butanetetracarboxylic acid (BTCA) and citric acid (CA) are low-cost alternatives reported to easily crosslink electrospun PVA hydrogel. These can be directly added into the spinning solutions. One of the most efficient non-steroidal anti-inflammatory drugs (NSAIDs), Naproxen (NAP), was selected as a model drug for this study. The release mechanisms of drug-loaded electrospun PVA nanofibers are based on the diffusion of the drugs through the swollen PVA fibrous matrix and the release due to partial dissolution of the matrix. Control over drug-release characteristics can be provided through partial crosslinking of the PVA fibrous matrix.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: CROSSLINKING; DRUG RELEASE; ELECTROSPINNING; NAPROXEN; POLYCARBOXYLIC ACIDS; PVA

Document Type: Research Article

Publication date: January 1, 2018

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more