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The Lifelong Effects of Early Childhood Adversity and Toxic Stress

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A rapidly expanding body of research indicates that early social environments characterized by adversity, subordination and stress, along with individual differences in susceptibility to such environments, create risks for lifelong chronic diseases, including declines in oral health. Emerging findings suggest that gene-environment interplay, resulting in epigenetically regulated differences in gene expression, underlie many such declines in health. The origins of these processes in early life reveal how many of the chronic morbidities of adulthood should be viewed as developmental disorders, with etiologic roots in childhood.
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Keywords: CHILDHOOD STRESS; DEVELOPMENTAL ORIGINS; GENE-ENVIRONMENT INTERPLAY

Document Type: Research Article

Affiliations: Professor of Pediatrics and Psychiatry and heads the Division of Developmental-Behavioral Pediatrics, University of California, San Francisco, Calif., USA. [email protected]

Publication date: March 1, 2014

More about this publication?
  • Pediatric Dentistry is the official publication of the American Academy of Pediatric Dentistry, the American Board of Pediatric Dentistry and the College of Diplomates of the American Board of Pediatric Dentistry. It is published bi-monthly and is internationally recognized as the leading journal in the area of pediatric dentistry. The journal promotes the practice, education and research specifically related to the specialty of pediatric dentistry. This peer-reviewed journal features scientific articles, case reports and abstracts of current pediatric dental research.
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