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Oral Candidiasis in Immunosuppressed Children and Young Adults After Liver or Kidney Transplantation

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Purpose: Candidiasis is an infectious complication in organ transplant recipients resulting from the patients' immunodeficiency and virulence of fungi pathogens. The purpose of this study was to evaluate the frequency of Candida spp. and identify their presence in the oral lesions of graft recipients. Methods: This study included 185 patients, 1.5 to 25.2 years of age (mean = 13.1 ± 4.2 years) who were receiving combined immunosuppression treatment after kidney or liver transplantation and 70 control subjects. Evaluation included clinical oral examination, mycology, and statistical analysis. Results: Candida spp. colonies were found in the oral mucosa of 63 (34%) graft recipients and in 19 (27%) control subjects. Candida albicans was the most prevalent species. This study showed that, regardless of the type of the organ transplant and immunosuppression, frequent, regular oral follow-up and mycologic tests are recommended. Diagnosing increased density of Candida spp. colonies in the oral cavity will help initiate early antifungal treatment. Conclusions: Candida spp. prevalence in the oral cavity in transplant recipients was higher than in immunocompetent control subjects. Kidney or liver transplantation predisposes one to the development of an increased density of Candida spp. colonies.
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Keywords: CANDIDOSIS OF THE ORAL MUCOSA; IMMUNOSUPPRESSION; PEDIATRIC TRANSPLANTATION

Document Type: Research Article

Affiliations: 1: Department of Oral Pathology, Children's Memorial Health Institute, Warsaw, Poland; Department of Pediatric Dentistry, Medical University of Warsaw, Warsaw, Poland 2: Department of Gastroenterology, Hepatology, and Immunology, The Children's Memorial Health Institute, Warsaw, Poland 3: Department of Clinical Microbiology and Immunology, The Children's Memorial Health Institute, Warsaw, Poland 4: Department of Nephrology, Kidney Transplantation, and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland 5: Kinesiology Lab, Department of Pediatric Rehabilitation, The Children's Memorial Health Institute, Warsaw, Poland 6: Dentist in private practice, Warsaw, Poland

Publication date: May 1, 2010

More about this publication?
  • Pediatric Dentistry is the official publication of the American Academy of Pediatric Dentistry, the American Board of Pediatric Dentistry and the College of Diplomates of the American Board of Pediatric Dentistry. It is published bi-monthly and is internationally recognized as the leading journal in the area of pediatric dentistry. The journal promotes the practice, education and research specifically related to the specialty of pediatric dentistry. This peer-reviewed journal features scientific articles, case reports and abstracts of current pediatric dental research.
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