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Open Access Sterility and Stability of Diluted Meloxicam in Compounded Multi-dose Vial after 365 Days

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Meloxicam is a common analgesic for rodents. Because meloxicam is only formulated commercially for companion animals, it requires dilution to achieve doses appropriate for small, laboratory species. Compounded multidose vial (cMDV) are often created to dilute and store a diluted drug. However, chronic cMDV use runs the risk of contamination and becoming a potential source of nosocomial infection. In this study, we created 15 cMDV by diluting meloxicam with sterile water (dilution, 1:10). cMDV were punctured once daily for 30 d. To determine the sterility of the diluted meloxicam, we assessed 8 cMDV for bacterial growth on days 0, 10, 20, 30, and 365 and tested them for endotoxin on days 0, 30, and 365. In addition, the stability of the remaining 7 cMDV was assessed on days 0, 10, 20, 30, and 365, by using liquid chromatography–diode assays. No bacterial growth or endotoxin was detected at any time point, and the drug concentrations remained stable over 365 d. Given the results this study, we believe that cMDV of diluted meloxicam can remain sterile and stable for 365 d.
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Document Type: Research Article

Affiliations: 1: School of Veterinary Medicine, University of California, Davis, California 2: Campus Veterinary Service, University of California, Davis, California 3: California Animal Health and Food Safety Laboratory System, University of California, Davis, California

Publication date: September 1, 2019

This article was made available online on August 5, 2019 as a Fast Track article with title: "Sterility and Stability of Diluted Meloxicam in Compounded Multi-dose Vial after 365 Days".

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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