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Open Access Evaluation of a Synthetic Bedding Substrate for Mice (Mus musculus)

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This study compared a synthetic bedding substrate (SBS), which has the potential to be a particulate-free animal bedding system, with the standard woodchip bedding. The objective was to demonstrate that the SBS is habitable for mice and reduces particulates to levels that would not contaminate the eye or potentially induce ocular (corneal) injury. Newly weaned mice were placed in either standard woodchip bedding or SBS. All mice were monitored regarding overall health (appearance, food and water intake, natural behavior, clinical signs, and provoked behavior) to verify their ability to adjust to the bedding. At 8 to 10 wk of age, the mice underwent slit-lamp evaluation for ocular (corneal) abnormalities. Results showed significant differences in body weight and overall health between bedding groups. The incidence of ocular abnormalities did not differ significantly between groups. We conclude that, without modifications and more testing, SBS is not a favorable bedding for mice, and results were inconclusive regarding its use as a bedding to preclude ocular contamination.

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Document Type: Research Article

Affiliations: 1: Veterinary Medicine and Surgery Department, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland;, Email: [email protected] 2: Laboratory Services Department, Research Support Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 3: Biochemistry and Physiology Branch, Medical Toxicology Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 4: Institutional Animal Care and Use Office, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland

Publication date: March 1, 2019

This article was made available online on February 25, 2019 as a Fast Track article with title: "Evaluation of a Synthetic Bedding Substrate for Mice (Mus musculus)".

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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