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Open Access Cardiopulmonary Effects of a Partial Intravenous Anesthesia Technique for Laboratory Swine

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Various anesthetic protocols are used in laboratory swine, each with specific advantages and disadvantages. Partial intravenous anesthetic techniques (PIVA) help minimize dose-dependent cardiopulmonary effects of inhalant drugs. The aim of this study was to determine the cardiopulmonary effects of a PIVA in laboratory swine. In a prospective, nonrandomized clinical study, 8 healthy juvenile Landrace–White pigs were premedicated with azaperone (0.20 ± 0.20 mg/kg IM), dexmedetomidine (0.02 ± 0.002 mg/kg IM), and alfaxalone (2.0 ± 0.20 mg/kg IM), and anesthesia was induced with intravenous alfaxalone. Anesthesia was maintained by using constant-rate infusion of dexmedetomidine (2 μg/kg/h) and alfaxalone (25 μg/kg/min) in combination with isoflurane. After the fraction of expired isoflurane was adjusted to 1.1% to 1.5%, respiratory rate, heart rate, systemic and pulmonary arterial pressure, central venous pressure, cardiac output, bispectral index, systemic vascular resistance, and arterial and mixed venous blood gases were recorded every 10 min for 60 min. Statistical analysis consisted of repeated-measures one-way ANOVA. Significant decreases occurred in heart rate, pulmonary mean arterial pressure, pulmonary diastolic pressure, partial pressure of arterial oxygen, partial pressure of venous oxygen; significant increases occurred in respiratory rate, minute volume index, diastolic arterial blood pressure, systemic vascular resistance, and arterial pH over time. We consider that the observed statistically significant cardiopulmonary changes were clinically important and that the PIVA protocol provided hemodynamic and respiratory stability for short-term anesthesia of laboratory swine.
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Document Type: Research Article

Affiliations: 1: Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada 2: Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Quebec, Canada 3: Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada;, Email: [email protected]

Publication date: July 1, 2018

This article was made available online on June 22, 2018 as a Fast Track article with title: "Cardiopulmonary Effects of a Partial Intravenous Anesthesia Technique for Laboratory Swine".

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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