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Open Access Genetic Characterization of a Captive Colony of Pigtailed Macaques (Macaca nemestrina)

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Effective colony management is critical to guarantee the availability of captive NHP as subjects for biomedical research. Pigtailed macaques (Macaca nemestrina) are an important model for the study of human and nonhuman primate diseases and behavior. Johns Hopkins University hosts one of the largest captive colonies of pigtailed macaques in the United States. In this study, we used 56 single-nucleotide polymorphisms (SNP) to characterize this population of pigtailed macaques, understand their population structure, and assess the effectiveness of their colony management. The results demonstrate that the colony has maintained a high level of genetic diversity, with no loss of heterozygosity since its origin, and low levels of inbreeding and genetic subdivision.
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Document Type: Research Article

Affiliations: 1: Department of Anthropology and California National Primate Research Center, University of California Davis, Davis, California 2: School of Mathematical and Natural Sciences, Arizona State University, Glendale, Arizona 3: Department of Molecular and Comparative Pathobiology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 4: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 5: Department of Anthropology and California National Primate Research Center, University of California Davis, Davis, California;, Email: [email protected]

Publication date: July 1, 2017

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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