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Open Access Effect of Overcrowding on Hair Corticosterone Concentrations in Juvenile Male Wistar Rats

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In many species, chronic stress due to overcrowding during the juvenile period triggers several metabolic and behavioral pathologies in adulthood. The aim of this study was to determine whether a chronic stress condition (overcrowding) induces changes in plasma and hair corticosterone concentrations, overall growth, and organ weights in young Wistar rats. The experimental subjects were divided into 2 groups (control and overcrowded); the overcrowded subjects were exposed to overcrowding during days 38 through 65 after birth. Plasma and hair corticosterone concentrations were higher in overcrowded rats compared with control subjects. In addition, overcrowding reduced body and organ weight gains. These results demonstrate that measuring the concentration of corticosterone in hair samples is an effective, noninvasive method for monitoring chronic stress in rats.

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Document Type: Research Article

Affiliations: 1: School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia 2: Neuroscience and Behavior Program, Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, Massachusetts, USA 3: Neuroscience and Behavior Laboratory, Department of Psychology, Universidad de Los Andes, Bogotá, Colombia 4: Departament of Animal Health, Faculty of Veterinary Medicine and Animal Science, Universidad Nacional de Colombia, Bogotá, Colombia. [email protected]

Publication date: 01 November 2016

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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