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Home / Journal of the American Association for Laboratory Animal Science, Volume 52, Number 1

Open Access Correlation of Thoracic Radiograph Measurements with Age in Adolescent Chinese Rhesus Macaques (Macaca mulatta)

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Thoracic radiography has been applied extensively to cardiovascular or respiratory disorders in veterinary practice and in research using animal models. To establish baseline measures for various parameters of thoracic radiography, we used a cross-sectional method to collect the lung length (LL), maximum interior thoracic breadth (TBr), maximum breadth of the cardiac silhouette (CBr), cardiothoracic ratio (CR), and right hilar height ratio (RHHR) of random healthy captive Chinese rhesus monkeys (age, 1 to 5 y; 89 male, 64 female). Significant sex-associated differences occurred in TBr among 1-y-old subjects and RHHR in 2- and 3-y-old monkeys. In addition, LL, TBr, and CBr were significantly correlated with age in both sexes. Finally, stepwise multiple regression revealed that LL and CBr were predictors of age in female monkeys, whereas LL and TBr were age-predictive in male macaques. The current data may suggest caveats regarding the use of thoracic radiography for evaluating disease processes, including pulmonary tuberculosis, hydropericardium, and heart failure, and for assessing physical development in adolescent rhesus macaques.

Document Type: Research Article

Affiliations: 1: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China 2: Xishan Zhongke Laboratory Animals, Suzhou, Jiangsu, China 3: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China. [email protected]

Publication date: 01 January 2013

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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