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Open Access Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider

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Administration of substances to laboratory animals requires careful consideration and planning to optimize delivery of the agent to the animal while minimizing potential adverse experiences from the procedure. For all species, many different routes are available for administration of substances. The research team and IACUC members should be aware of reasons for selecting specific routes and of training and competency necessary for personnel to use these routes effectively. Once a route is selected, issues such as volume of administration, site of delivery, pH of the substance, and other factors must be considered to refine the technique. Inadequate training or inattention to detail during this aspect of a study may result in unintentional adverse effects on experimental animals and confounded results.

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Document Type: Research Article

Affiliations: 1: Department of Pathobiology, University of Guelph, Guelph, Canada. [email protected] 2: Department of Comparative Medicine, School of Medicine, University of Washington, USA 3: Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA 4: Platform, Technology and Sciences, Quality and Risk Management, Glaxo Smith Kline, Research Triangle Park, North Carolina, USA

Publication date: September 1, 2011

More about this publication?
  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

    Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.

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