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Open Access Naturally Developing Virus-Induced Lethal Pneumonia in Two Guinea Pigs (Cavia porcellus)

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Two guinea pigs (Cavia porcellus) were affected by an acute naturally developing lethal pneumonitis. One guinea pig was found dead and had not had clinical signs of disease, whereas the second guinea pig was dyspneic and tachypneic. Necropsy revealed well-demarcated areas of pulmonary consolidation in the cranial and ventral areas of the lungs. Necrotic bronchiolar epithelium accompanied by basophilic intranuclear inclusion bodies was the primary histopathologic finding. Transmission electron microscopy revealed virions with ultrastructural characteristics of an adenovirus. Adenoviral infections in guinea pigs are likely to be more prevalent than are currently recognized. Adenoviruses may cause inapparent infections in guinea pigs that could potentially interfere with laboratory studies.

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Document Type: Research Article

Affiliations: 1: Department of Toxicology, Geneva Laboratories, Inc., Proctor Dr. at McKenzie Lane, Elkhorn, WI 53121 2: Experimental Pathology Laboratories, Inc., Research Triangle Park, N.C. 27709 3: Microbiology, Pathology and Parasitology Depart- ment, College of Veterinary Medicine, North Carolina State University Raleigh, NC 27502 4: Geneva Laboratories, Inc., Proctor Dr. at McKenzie Lane, Elkhorn, WI 53121

Publication date: January 1, 1998

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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