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Open Access Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

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Successful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n = 36) were instrumented with a dual-pressure telemetry transmitter and vascular access port. Modifications to acclimation practices, surgical procedures, and housing were required for implementation of ABS in our established cardiovascular canine telemetry colony. These modifications have increased the use and reproducibility of the model by combining early pharmacokinetic and cardiovascular studies, thus achieving both refinement and reduction from a 3R perspective. In addition, the modified model can shorten timelines and reduce the compound requirement in early stages of drug development. This telemetry–ABS model provides an efficient means to quickly identify potential effects on key cardiovascular parameters in a large animal species and to obtain a more complete pharmacokinetic–pharmacodynamic profile for discovery compounds.

Document Type: Research Article

Affiliations: 1: Department of Safety Pharmacology, Abbvie, North Chicago, Illinois;, Email: [email protected] 2: Department of Safety Pharmacology, Abbvie, North Chicago, Illinois 3: Department of Comparative Medicine, Abbvie, North Chicago, Illinois

Publication date: April 1, 2021

This article was made available online on April 4, 2021 as a Fast Track article with title: "Automated Blood Sampling in a Canine Telemetry Cardiovascular Model".

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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