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Open Access Hepatic Hemangiosarcoma in a Cynomolgus Macaque (Macaca fascicularis)

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An experimentally naïve, 9-y-old, intact male cynomolgus macaque was reported for bleeding from an unidentified site. Sedated physical examination indicated mild gingival separation from the lingual aspect of the upper right canine tooth as the source of the hemorrhage. Physical exam revealed a firm mass adhered to the left zygomatic arch, 2 subcutaneous nodules on the chest, and a large mass in the cranial abdomen. Radiographs revealed a large soft-tissue mass in the cranial abdomen and multifocal nodules in the caudal lung fields. On ultrasonography, the liver was grossly enlarged and contained a cavi- tated mass. Hematology and serum chemistry results demonstrated severe regenerative anemia with normal clotting times and adequate platelet count. For humane reasons, euthanasia was elected. On gross examination, the liver was markedly enlarged by an expansile mass primarily affecting the median lobe, with multiple, smaller nodules throughout the remaining lobes. Multifocal round, firm nodules were observed on the surface of all lung lobes and throughout the omentum. Histologic examination of the hepatic, cutaneous, osseous, and pulmonary lesions demonstrated well-defined, endothelium-lined vascular channels arranged in cords with abundant hemorrhage; endothelial-cell immunomarkers confirmed these results. On the basis of these findings, hepatic hemangiosarcoma, with metastases to the lungs, omentum, subcutis, and bone, was diagnosed. This case study is the first report of spontaneous hepatic hemangiosarcoma in a cynomolgus macaque and the first case with metastasis to bone in a NHP.

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Document Type: Case Report

Affiliations: 1: Department of Pathobiology, University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania, Comparative Medicine Resources, Rutgers, The State University of New Jersey, Piscataway, New Jersey., Email: [email protected] 2: Department of Pathobiology, University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania, Gene Therapy Program, University of Pennsylvania, Philadelphia, Pennsylvania 3: Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania 4: Department of Pathobiology, University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania.

Publication date: June 1, 2019

This article was made available online on April 1, 2019 as a Fast Track article with title: "Single-photon Emission Computed Tomography–Computed Tomography Using 99mTc-labeled Leukocytes for Evaluating Infection Associated with a Cranial Implant in a Rhesus Macaque (Macaca mulatta)".

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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