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Open Access Delayed and Aberrant Presentation of VX2 Carcinoma in a Rabbit Model of Hepatic Neoplasia

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A socially-housed New Zealand white rabbit presented with a large subcutaneous mass on the ventral thorax approximately 11 mo after the intrahepatic delivery of a suspension of VX2 carcinoma cells to induce hepatocellular carcinoma as part of a nanoparticle study. The mass and closely associated axillary lymph node were removed en bloc. Immunohistochemical staining identified the mass as an undifferentiated carcinoma. The rabbit demonstrated no appreciable pathology at the study end point at 16 mo after VX2 inoculation. An additional rabbit from the same VX2 injection cohort was found at necropsy to have an unanticipated intraabdominal mass, also identified as an undifferentiated carcinoma. This case report summarizes the molecular analysis of both tumors through a novel PCR assay, which identified the delayed and aberrant onset of VX2 carcinoma in an extended timeframe not previously reported.

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Document Type: Case Report

Affiliations: 1: Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA. [email protected] 2: Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA 3: Department of Institute of Clinical and Translational Sciences, University of Missouri, Columbia, Missouri, USA 4: Department of IDEXX BioResources, Columbia, Missouri, USA 5: Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, USA 6: Department of Radiology and Bio-Engineering, University of Missouri, Columbia, Missouri, USA

Publication date: October 1, 2015

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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