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Open Access Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice

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Plasminogen-deficient (FVB/NPan-plgtm1Jld, plgtm1Jld ) mice, which are widely used as a wound-healing model, are prone to spontaneous rectal prolapses. The aims of this study were 1) to evaluate the fecal microbiome of plgtm1Jld mice for features that might contribute to the development of rectal prolapses and colonic inflammation and 2) to assess the relevance of the inflammatory phenotype to the variability in wound healing in this model. The plgtm1Jld mice exhibited delayed wound healing, and they could be divided into 3 distinct groups that differed according to the time until wound closure. Colonic lesions in plgtm1Jld mice, which were characterized by necrotizing ulcerations and cystically dilated glands, were restricted to the intermediate and distal parts of the colon. The cytokine profile was indicative of chronic tissue damage, but the genetic modification did not change the composition of the gut microbiota, and none of the clinical or biochemical parameters correlated with the gut microbiota composition.

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Document Type: Research Article

Affiliations: 1: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. [email protected] 2: Department of Departments of Food Science, University of Copenhagen, Frederiksberg, Denmark 3: Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark 4: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark 5: Department of Biology, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark

Publication date: October 1, 2015

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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