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Open Access Insulin Resistance in Insulin-Resistant and Diabetic Hamsters (Mesocricetus auratus) Is Associated with Abnormal Hepatic Expression of Genes Involved in Lipid and Glucose Metabolism

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Fat-induced hepatic insulin resistance (FIHIR) in obesity induced by high-fat diet leads to ectopic lipid accumulation and may contribute to the pathogenesis of type 2 diabetes. We examined the alterations in hepatic gene expression involved in FIHIR by using obese insulin-resistant and diabetic hamsters that received high-fat diet with or without low-dose streptozotocin. Microarray analysis and confirmatory real-time RT-PCR indicated that increased mRNA levels of sterol regulatory element-binding proteins (SREBPs) and decreased mRNA levels of liver X receptor (LXRα) and peroxisome-proliferator–activated receptor (PPARα) occurred in FIHIR in insulin-resistant and diabetic hamsters. Expression levels of hepatic LXRα, SREBPs, and PPARα differed significantly between insulin-resistant and diabetic hamsters. Expression of LXRα, SREBPs, and PPARα all change in FIHIR associated with hepatic lipid accumulation in insulin-resistant and diabetic hamsters in which disease is induced by high-fat diet and streptozotocin injection.

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Document Type: Research Article

Affiliations: Department of Pathology, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China

Publication date: October 1, 2009

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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