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Open Access Pseudocapillaria tomentosa, a Nematode Pathogen, and Associated Neoplasms of Zebrafish (Danio rerio) Kept in Research Colonies

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Infections with capillarid nematodes were observed in zebrafish (Danio rerio) kept at several research facilities and in a large carcinogen exposure study previously conducted at Oregon State University. We report a morphologic description that identifies the worm as Pseudocapillaria tomentosa, a common nematode of cyprinid and other fishes. Pathologic lesions associated with the infection ranged from inflammatory changes to aggressive neoplasms of the intestine (i.e., intestinal carcinomas and mixed malignant neoplasms). Capillarid nematodes may have intermediate or paratenic hosts. Using a laboratory transmission study, we confirmed that the parasite has a direct life cycle.

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Document Type: Research Article

Affiliations: 1: Center for Fish Disease Research, Department of Microbiology, 220 Nash, Oregon State University, Corvallis, Oregon 97331-3804; Zebrafish International Resource Center, 5274 University of Oregon, Eugene, Oregon 97403-5274 2: Zebrafish International Resource Center, 5274 University of Oregon, Eugene, Oregon 97403-5274 3: Department of Environmental and Molecular Toxicology, Marine/Freshwater Biomedical Center, Oregon State University, Corvallis Oregon 97331

Publication date: August 1, 2002

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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