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Open Access Cardiopulmonary Effects of Sevoflurane in Garnett's Greater Bush Baby (Otolemur garnettii)

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Purpose: A study was conducted to assess the cardiopulmonary and anesthetic effects of sevoflurane anesthesia on Garnett's Greater Bush Baby (Otolemur garnettii).

Methods: Anesthesia was induced in ten animals with 8% sevoflurane and was maintained by use of 2.5% sevoflurane for 30 minutes. Induction and recovery times were recorded. Heart and respiratory rates (RR), end-tidal carbon dioxide concentration (ET CO2), arterial blood pressures, relative arterial blood oxygen saturation (SpO2 ), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and pH were monitored. Preand poststudy CBC and serum biochemical values were compared.

Results: Anesthesia induction was rapid (75 ± 8.7 seconds [mean ± SEM]) and smooth. Heart rate significantly increased initially, then decreased significantly over the remaining 30 minutes. There were no significant changes in RR, SpO2, ETCO2, or arterial blood pressure. The PaO2 values significantly increased in the 10- to 30-minute samples. The PaCO2 values remained steady in the 10- to 30-minute samples. A significant decrease was seen in white blood count, calcium, and total protein (TP) values, compared with values in pre-anesthesia samples. Recovery from anesthesia was smooth and rapid, with extubation at 24 ± 5.8 seconds.

Conclusions: At the concentrations used in this study, sevoflurane appears to be a safe and effective agent for induction and maintenance of anesthesia in O. garnettii.

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Document Type: Research Article

Publication date: December 1, 2000

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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