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Open Access The Guinea Pig Estrous Cycle: Correlation of Vaginal Impedance Measurements with Vaginal Cytologic Findings

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| Immunologic responses elicited after vaginal immunization of laboratory mammals are affected by the stage of the animal's estrous cycle at which antigen is delivered. The study reported here documents vaginal impedance as an improved means of determining accurately precise stages of the estrous cycle of guinea pigs. Impedance changes were correlated with cytologic changes observed in vaginal smears taken from the animals. The start of the impedance peak corresponded with proestrus, the rising side of the peak with estrus, and the apex of the peak with metestrus; diestrus was seen approximately 3 days after the peak apex. These results contrast with those of previous studies. Various dosage regimens of estradiol (1 to 1,000 g/animal over 1 to 6 days) were used in guinea pigs in an attempt to invoke an extended (>6 h) estrogeninduced mucosa. Parenteral administration of 1,000 g of estradiol to guinea pigs daily for 6 days induced a 2- to 3-day estrus stage in these animals.

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Document Type: Research Article

Affiliations: Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, GPO Box 2434 Brisbane Q 4001, Australia

Publication date: December 1, 1997

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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