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Open Access Pancreatic Exocrine Studies in Intact Animals: Historic and Current Methods

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This report presents a review of the historic and current methods for performing pancreatic exocrine studies in intact animals. Special emphasis is given to the various surgical procedures—pancreatic fistulas, duodenal pouches, and duodenal fistulas—and practice of collecting pancreatic secretion in dogs. Procedures in other animal species—rat, cat, pig, rabbit, cattle, sheep, and horse—also are specified. The advantages and disadvantages, as well as the indications and limitations of the distinct methods, are discussed.

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Document Type: Research Article

Affiliations: 1: Professor of Medicine and Chairman, Department of Medicine IV, (Gastroenterology), University Hospital of Heidelberg at Mannheim, Theodor-Kutzer-Ufer, D-68167 Mannheim, Germany 2: Department of Medicine IV, (Gastroenterology), University Hospital of Heidelberg at Mannheim, Mannheim, Germany

Publication date: December 1, 1997

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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