Genetic control of postnatal human brain growth
Studies investigating postnatal brain growth disorders inform the biology underlying the development of human brain circuitry. This research is becoming increasingly important for the diagnosis and treatment of childhood neurodevelopmental disorders, including autism and related disorders. Here, we review recent research on typical and abnormal postnatal brain growth and examine potential biological mechanisms.
Clinically, brain growth disorders are heralded by diverging head size for a given age and sex, but are more precisely characterized by brain imaging, post-mortem analysis, and animal model studies. Recent neuroimaging and molecular biological studies on postnatal brain growth disorders have broadened our view of both typical and pathological postnatal neurodevelopment. Correlating gene and protein function with brain growth trajectories uncovers postnatal biological mechanisms, including neuronal arborization, synaptogenesis and pruning, and gliogenesis and myelination. Recent investigations of childhood neurodevelopmental and neurodegenerative disorders highlight the underlying genetic programming and experience-dependent remodeling of neural circuitry.
To understand typical and abnormal postnatal brain development, clinicians and researchers should characterize brain growth trajectories in the context of neurogenetic syndromes. Understanding mechanisms and trajectories of postnatal brain growth will aid in differentiating, diagnosing, and potentially treating neurodevelopmental disorders.
Document Type: Research Article
Affiliations: 1: Department of Molecular Biology, Cell Biology and Biochemistry, and Brown Institute for Brain Science, Brown University, Providence 2: Department of Molecular Biology, Cell Biology and Biochemistry, and Brown Institute for Brain Science, Brown University, Providence, Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Hassenfeld Child Health Innovation Institute, Brown University, Providence, Rhode Island, USA
Publication date: February 1, 2017