The objectives of this report are to determine the association between performance-based measures of physical function with caregiver reports of physical function in older adults with Alzheimer disease (AD) and to examine whether those associations vary by the level of patients’
cognitive functioning. Subjects included 180 patient-caregiver dyads who are enrolled in a clinical trial testing the impact of an occupational therapy intervention plus guideline-level care to delay functional decline among older adults with AD. The primary caregiver-reported measure is the
Alzheimer’s Disease Cooperative Study Group Activities of Daily Living Inventory (ADCS-ADL). Performance-based measures include the Short Physical Performance Battery and the Short Portable Sarcopenia Measure. Analysis of covariance (ANCOVA) models were used to determine the associations
of each physical performance measure with ADCS-ADL, adjusting for cognition function and other covariates. We found significant correlations between caregiver reports and observed performance-based measures across all levels of cognitive function, with patients in the lowest cognitive group
showing the highest correlation. These findings support the use of proxy reports to assess physical function among older adults with AD.
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Document Type: Research Article
Indiana University Center for Aging Research, Regenstrief Institute Inc.
Departments of Biostatistics
Indiana University Center for Aging Research, Regenstrief Institute Inc., Medicine, Indiana University School of Medicine, Indianapolis, IN
April 1, 2016