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NSAID Use and Incident Cognitive Impairment in a Population-based Cohort

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Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent dementia, but previous studies have yielded conflicting results. This study estimated the association of prior NSAID use with incident cognitive impairment in the population-based Epidemiology of Hearing Loss Study (EHLS, n=2422 without cognitive impairment in 1998-2000). Prospectively collected medication data from 1988-1990, 1993-1995, and 1998-2000 were used to categorize NSAID use history at the cognitive baseline (1998-2000). Aspirin use and nonaspirin NSAID use were separately examined. Cox regression models were used to estimate the associations between NSAID use history at baseline and incident cognitive impairment in 2003-2005 or 2009-2010. Logistic regression analyses were used to estimate associations with a second outcome, mild cognitive impairment/dementia, available in 2009-2010. Participants using aspirin at baseline but not 5 years prior were more likely to develop cognitive impairment (adjusted hazard ratio=1.77; 95% confidence interval=1.11, 2.82; model 2), with nonsignificant associations for longer term use. Nonaspirin NSAID use was not associated with incident cognitive impairment or mild cognitive impairment/dementia odds. These results provided no evidence to support a potential protective effect of NSAIDs against dementia.
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Keywords: aspirin; cognition; dementia; nonsteroidal anti-inflammatory drug; population-based

Document Type: Research Article

Affiliations: 1: Departments of Population Health Sciences, Institute on Aging, Wisconsin Alzheimer’s Disease Research Center (ADRC) 2: Departments of Population Health Sciences, Ophthalmology and Visual Sciences 3: Wisconsin Alzheimer’s Disease Research Center (ADRC), Medicine, Division of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Veterans Affairs Geriatric Research, Education and Clinical Center (GRECC), Madison, WI 4: Wisconsin Alzheimer’s Disease Research Center (ADRC), Biostatistics and Medical Informatics, Department of Statistics, University of Wisconsin 5: Ophthalmology and Visual Sciences

Publication date: April 1, 2016

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