Blinding in Surgical Randomized Clinical Trials in 2015

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Source: Annals of Surgery, Volume 266, Number 1, July 2017, pp. 21-22(2)

DOI: https://doi.org/10.1097/SLA.0000000000002242

<br></br>Lack of blinding in randomized clinical trials can bias the effect estimates of the observed intervention. In trials assessing nonpharmacological interventions (eg, surgical randomized clinical trials) blinding is usually more difficult. In this mini-review the blinding and reporting of blinding was assessed from surgical randomized clinical trials that were published in leading medical and surgical journals in 2015. Conducting a systematic search on PubMed, a total of 99 studies were deemed as relevant and blinding status assessed. Blinding was explicitly stated for practitioners, patients, and outcome observers in 3%, 37%, and 52%, respectively. The blinding status was not clearly stated in a large proportion of studies or had sometimes a misleading classification. Hence, authors and journals publishing randomized controlled trials should pay attention that status of blinding is unambiguously reported. </div> <div id="Refs" class="tab-pane" role="tabpanel" aria-hidden="true" aria-labelledby="tab-refs"> No Reference information available - sign in for access. </div> <div id="Cits" class="tab-pane" role="tabpanel" aria-hidden="true" aria-labelledby="tab-cits"> No Citation information available - sign in for access. </div> <div id="Supp" class="tab-pane" role="tabpanel" aria-hidden="true" aria-labelledby="tab-supp"> No Supplementary Data. </div> <div id="Data" class="tab-pane rs_skip" aria-hidden="true" aria-labelledby="tab-data">No Article Media</div> <div id="Metr" class="tab-pane rs_skip" aria-hidden="true" aria-labelledby="tab-metr">No Metrics</div> </div> <div id="Info"> <p><strong>Keywords:</strong> <a href="/search;jsessionid=1192ge78m1cdt.x-ic-live-01?option1=keywords&value1='bias'">bias</a>; <a href="/search;jsessionid=1192ge78m1cdt.x-ic-live-01?option1=keywords&value1='blinding'">blinding</a>; <a href="/search;jsessionid=1192ge78m1cdt.x-ic-live-01?option1=keywords&value1='randomized+clinical+trial'">randomized clinical trial</a>; <a href="/search;jsessionid=1192ge78m1cdt.x-ic-live-01?option1=keywords&value1='reporting'">reporting</a>; <a href="/search;jsessionid=1192ge78m1cdt.x-ic-live-01?option1=keywords&value1='surgery'">surgery</a> </p> <p><strong>Document Type:</strong> Research Article</p> <p><strong>Affiliations:</strong> Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, Department of Surgery, Cantonal Hospital Baselland, Liestal, Switzerland. </p> <p>Publication date: 01 July 2017 </p> <script type="text/javascript" > $(document).ready(function() { const MAGIC_LENGTH = 350; var shortdescription = $(".originaldescription").text().replace(/\\&/g, 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