The SLITRK1 (Slit and Trk-like 1) gene has been suggested to be a promising candidate for Tourette syndrome (TS) since the first report that identified its two rare variants adjacent to the chromosome inversion in a TS child with inv(13) (q31.1;q33.1). A series
of replication studies have been carried out, whereas the role of the gene has not been elucidated. The present study aimed to determine whether the two or novel nonsynonymous variants were identified in Japanese TS patients and carry out an association analysis of the gene in a Japanese population.
We did not observe the two or any novel nonsynonymous variants in the gene. In contrast, a significant difference was observed in the distributions of the haplotypes consisting of rs9546538, rs9531520, and rs9593835 between the patients and the controls. This result may partially support the
implication of SLITRK1 in the pathogenesis of TS, warranting further studies of the gene.
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single nucleotide polymorphism;
Document Type: Research Article
Department of Child Neuropsychiatry
Department of Neuropsychiatry, Teikyo University School of Medicine, Tokyo, Japan
Department of Child Neuropsychiatry, Disability Services Office
Department of Neuropsychiatry, Graduate School of Medicine
Department of Physical and Health Education, Graduate School of Education
Office for Mental Health Support, University of Tokyo
December 1, 2015