Skip to main content
padlock icon - secure page this page is secure

Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias

Buy Article:

$52.00 + tax (Refund Policy)

Background

Genetic, environmental, and cognitive factors play a role in the development and recurrence of depression. More specifically, cognitive biases have been associated with depression risk genes and life events. Recently, the mineralocorticoid receptor NR3C2 gene, and in particular the rs5534 polymorphism, has been associated with negative memory bias, at least in healthy individuals who experienced severe life adversity. The current study examined the interaction between the rs5534 genotype and different types of adverse life events in a sample of depressed patients in remission.

Materials and methods

A total of 298 depressed patients in remission performed an incidental emotional memory task (negative and positive words). Life adversity, childhood trauma, and recent adversity were measured using a self-report questionnaire. NR3C2 rs5534 by life adversity, as well as childhood trauma and recent adversity interactions were analyzed for negative and positive memory bias using analyses of covariance.

Results

The significant interaction between rs5534 and childhood trauma on negative memory bias (P=0.046) indicated that risk ‘A’ allele carriers with childhood trauma tended to show more negative memory bias compared to individuals homozygous for the G allele who had experienced childhood trauma and A allele carriers without childhood trauma. No interaction effects with life adversity or recent adversity were found. Also, no main effect of rs5534 on memory bias was found, although we had insufficient power for this analysis.

Conclusion

An association of the NR3C2 gene and childhood trauma with negative memory bias was found in depressed patients in remission, which extends previous findings in a healthy population.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: NR3C2 gene; childhood trauma; cognitive bias; depression; life adversity; memory bias; mineralocorticoid receptor

Document Type: Research Article

Affiliations: 1: Departments of Psychiatry 2: Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour 3: Departments of Psychiatry, Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Human Genetics, Radboud University Medical Center 4: Departments of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Human Genetics, Radboud University Medical Center 5: Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands

Publication date: June 1, 2015

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more