Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients
NSAIDs-induced urticaria and/or angioedema (NIUA) is the most frequent entity of hypersensitivity reactions to NSAIDs. The underlying cause is considered to be because of a nonspecific immunological mechanism in which mast cells are key players. We studied the association of nine single
nucleotide polymorphisms in five genes involved in mast cell activation (SYK, LAT1, PLCG1, PLA2G4A, and TNFRSF11A) in 450 NIUA patients and 500 controls. We identified several statistically significant associations when stratifying patients by symptoms: PLA2G4A
rs12746200 (urticaria vs. controls, P
c=0.005). PLCG1 rs2228246 (angioedema vs. controls; P
c=0.044), and TNFRS11A rs1805034 (urticaria+angioedema vs. controls; P
c=0.041). The frequency of haplotype PLCG1 rs753381-rs2228246
(C-G) in angioedema-NIUA patients was lower than that in controls (P
c=0.040). In addition, the haplotype frequency of TNFRS11A rs1805034-rs35211496 (C-T) was higher among urticaria-NIUA and urticaria+angioedema-NIUA patients than the controls (P
and 0.046). Our results shed light on the involvement of variants in genes related to non-immunological mast cell activation in NIUA.
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NSAIDs-induced urticaria and/or angioedema;
hypersensitivity drugs reactions;
single nucleotide polymorphisms
Document Type: Short Communication
Research Laboratory, Allergy Service, Infanta Leonor Hospital, Madrid, Spain
Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga
Allergy Service, Infanta Leonor Hospital, Madrid, Spain
Research Laboratory, Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga
December 1, 2015