Our aim was to determine whether the HLA-Cw6 and late-cornified envelope (LCE) deletion polymorphisms were related to disease improvement among psoriasis patients treated with anti-tumor necrosis factor (TNF) antibodies. The study included a total of 116 patients. Positive response
(68%) was defined as a reduction of at least 75% of the Psoriasis Area and Severity Index (PASI) after 24 weeks of starting the anti-TNF therapy. We found a trend toward a better response among Cw6-positive patients. The frequency of patients who did not reach the PASI75 was higher among the
LCE-DD patients (P=0.028; odds ratio=2.45, 95% confidence interval=1.09–5.52). Patients who were Cw6-positive and LCE-I carriers (ID/II) were significantly more likely to reach PASI75 than those who were Cw6-negative and LCE-DD (P=0.034; odds ratio=3.14,
95% confidence interval=1.07–9.24). In conclusion, we found an interaction between the HLA-Cw6 and LCE genotypes on disease improvement among psoriatic patients treated with anti-TNFs.
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Document Type: Short Communication
Molecular Genetics, Department of Medicine, University of Oviedo, Oviedo, Spain
Rheumatology, Hospital Universitario Central Asturias
Dermatology II, Department of Medicine, University of Oviedo, Oviedo, Spain
Publication date: June 1, 2015