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The Cw6 and late-cornified envelope genotype plays a significant role in anti-tumor necrosis factor response among psoriatic patients

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Our aim was to determine whether the HLA-Cw6 and late-cornified envelope (LCE) deletion polymorphisms were related to disease improvement among psoriasis patients treated with anti-tumor necrosis factor (TNF) antibodies. The study included a total of 116 patients. Positive response (68%) was defined as a reduction of at least 75% of the Psoriasis Area and Severity Index (PASI) after 24 weeks of starting the anti-TNF therapy. We found a trend toward a better response among Cw6-positive patients. The frequency of patients who did not reach the PASI75 was higher among the LCE-DD patients (P=0.028; odds ratio=2.45, 95% confidence interval=1.09–5.52). Patients who were Cw6-positive and LCE-I carriers (ID/II) were significantly more likely to reach PASI75 than those who were Cw6-negative and LCE-DD (P=0.034; odds ratio=3.14, 95% confidence interval=1.07–9.24). In conclusion, we found an interaction between the HLA-Cw6 and LCE genotypes on disease improvement among psoriatic patients treated with anti-TNFs.
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Keywords: biological therapy; gene polymorphism; late-cornified envelope; pharmacogenetics; psoriasis

Document Type: Short Communication

Affiliations: 1: Dermatology II 2: Molecular Genetics, Department of Medicine, University of Oviedo, Oviedo, Spain 3: Molecular Genetics 4: Rheumatology, Hospital Universitario Central Asturias 5: Dermatology II, Department of Medicine, University of Oviedo, Oviedo, Spain

Publication date: June 1, 2015

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