Multicenter evaluation of single-photon emission computed tomography quantification with third-party reconstruction software
Reliable and reproducible quantification is essential in many clinical situations. Previously, single-photon emission computed tomography (SPECT) has not been considered a quantitative imaging modality, but recent advances in reconstruction algorithm development have made SPECT quantitative.
In this study, we investigate the reproducibility of SPECT quantification with phantoms in a multicenter setting using novel third-party reconstruction software. A total of five hospitals and eight scanners (three GE scanners and five Siemens scanners) participated in the study. A Jaszczak
phantom without inserts was used to calculate counts to activity concentration conversion factors. The quantitative accuracy was tested using the NEMA-IEC phantom with six spherical inserts (diameters from 10 to 37 mm) filled to an 8 : 1 insert-background concentration
ratio. Phantom studies were reconstructed at one central location using HERMES HybridRecon applying corrections for attenuation, collimator-detector response, and scatter. Spherical volumes of interest with the same diameter as the inserts were drawn on the images and recovery coefficients
for the spheres were calculated. The coefficient of variation (CoV) of the NEMA-IEC phantom recovery coefficients ranged from ∼19 to 5% depending on the insert diameter so that the lowest CoV was obtained with the largest spheres. The intersite CoV was almost equal to intrasite CoV. In
conclusion, quantitative SPECT is reproducible in a multicenter setting with third-party reconstruction software.
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quantitative-single-photon emission computed tomography
Document Type: Research Article
Department of Radiation Therapy, Vaasa Central Hospital, Vaasa
HERMES Medical Solutions, Stockholm, Sweden
HUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki
Laboratory of Clinical Physiology and Nuclear Medicine, Joint Authority for Päijät-Häme Social and Health Care, Lahti, Finland, HERMES Medical Solutions, Stockholm, Sweden
Publication date: September 1, 2016