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Multicentric Giant Cell Glioblastoma: Case Report and Revision of the Literature

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Glioblastoma multiforme is the most common primary brain tumor; however, the occurrence of this tumor in >1 site without continuity is rare, especially in association with unusual histologic variants. These features might have prognostic implications, especially in terms of surgical and adjuvant therapy. We present a case of a patient with 2 lesions, without continuity, initially thought to be metastatic disease, but that revealed to be glioblastoma multiforme, in its giant cell variant, an extremely rare subtype. We discuss the pathogenesis, diagnostic challenges, and appropriate treatment available in the literature.
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Keywords: giant cell glioblastoma; glioblastoma multiforme; multicentric glioblastoma multiforme

Document Type: Research Article

Affiliations: 1: Departments of Neurosurgery 2: Neurology, São Vicente de Paulo Hospital 3: Passo Fundo Pathology Institute, Passo Fundo, Brazil

Publication date: February 1, 2016

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