Emerging evidence has shown that long noncoding RNA (lncRNA) plays a crucial role in controlling neural stem cells’ (NSCs) survival. However, the fundamental role of lncRNA underlying sevoflurane-induced neurotoxicity remains poorly elucidated. In the present study, we investigate
the effect of sevoflurane-induced neurotoxicity in a concentration-dependent and duration-dependent manner. Furthermore, we assayed the differential profile of lncRNA in rat hippocampal NSCs following sevoflurane exposure, and identified lncRNA Gadd45a and the correlation between lncRNA
Gadd45a and Gadd45a. We found that lncRNA Gadd45a and its nearby gene, Gadd45a, were significantly upregulated in NSCs exposed to sevoflurane. Notably, Gadd45a was enriched in the cell cycle-relative pathway including mitogen-activated protein kinases and P53
signaling, whereas lncRNA Gadd45a was positively correlated with Gadd45a. These results suggest lncRNA Gadd45a is associated with sevoflurane-induced toxicity, and thus shed light on a new key target for revealing the molecular mechanism of sevoflurane-induced toxicity.
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long noncoding RNA;
neural stem cells;
Document Type: Research Article
Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, Departments of Anesthesiology
Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province
Clinical Laboratory, Fujian Provincial Maternity and Children’s Hospital, Fujian Medical University, Fuzhou, Fujian Province, China
May 23, 2018