Patients with Alzheimer’s disease (AD) experience a wide array of cognitive deficits, which typically include the impairment of explicit memory. In previous studies, the authors reported that a flavonoid, quercetin, reduces the expression of ATF4 and delays memory deterioration
in an early-stage AD mouse model. In the present study, the effects of long-term quercetin intake on memory recall were assessed using contextual fear conditioning in aged wild-type mice. In addition, the present study examined whether memory recall was affected by the intake of quercetin-rich
onion (a new cultivar of hybrid onion ‘Quergold’) powder in early-stage AD patients. In-vivo analysis indicated that memory recall was enhanced in aged mice fed a quercetin-containing diet. Memory recall in early-stage AD patients, determined using the Revised Hasegawa Dementia
Scale, was significantly improved by the intake of quercetin-rich onion (Quergold) powder for 4 weeks compared with the intake of control onion (‘Mashiro’ white onion) powder. These results indicate that quercetin might influence memory recall.
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Mini Mental State Examination;
Revised Hasegawa Dementia Scale;
activating transcription factor 4;
growth arrest and DNA damage-inducible gene 34;
Document Type: Research Article
Departments of Neurobiology
Neurology and Geriatrics
Long Term Care Health Facility Senjyu Nagomino
Departments of Neurobiology, Asahi University, Gifu
Pharmacy, Gifu University Graduate School of Medicine
Hokkaido Agricultural Research Center, National Agriculture and Food Research Organization (NARO)
Hokkaido Research Organization, Sapporo
RIKEN Center for Sustainable Resource Science, Yokohama
National Food Research Institute, NARO, Tsukuba, Japan
Publication date: June 15, 2016