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Detection of prevalent mechanism of extended spectrum β-lactamases, metallo β-lactamases, and AmpC β lactamases-producing Klebsiella pneumoniae in the tertiary care hospital

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<br></br>Increasing trends of resistance to antibiotics because of production of β-lactamases, such as carbapenamase-mediated resistance and extended spectrum β-lactamases (ESBL), are the most widespread mechanisms documented in <i>Klebsiella pneumoniae.</i> The objective of this study was to understand the prevalent mechanisms of resistance among the clinical isolates of multidrug-resistant (MDR) <i>K. pneumonia</i> from inpatients of a tertiary care hospital at Baghdad, Iraq. Among the 97 MDR <i>K. pneumoniae</i> isolates, 47.4% (<i>n</i> = 46) isolates showed ESBL production, 38.7% (<i>n</i> = 38) showed metallo β-lactamase (MBL) production, and 22.7% (<i>n</i> = 22) showed both ESBL and MBLs production. Out of 97 MDR <i>K. pneumoniae</i>, 94.3% were found to be biofilm producers. ESBL production was the predominant mechanism of resistance followed by MBL production. Since very limited therapeutic options are available, increasing resistance mechanisms among these organisms is an ‘alarming sign’. </div> <div id="Refs" class="tab-pane" role="tabpanel" aria-hidden="true" aria-labelledby="tab-refs"> No Reference information available - sign in for access. </div> <div id="Cits" class="tab-pane" role="tabpanel" aria-hidden="true" aria-labelledby="tab-cits"> No Citation information available - sign in for access. </div> <div id="Supp" class="tab-pane" role="tabpanel" aria-hidden="true" aria-labelledby="tab-supp"> No Supplementary Data. </div> <div id="Data" class="tab-pane rs_skip" aria-hidden="true" aria-labelledby="tab-data">No Article Media</div> <div id="Metr" class="tab-pane rs_skip" aria-hidden="true" aria-labelledby="tab-metr">No Metrics</div> </div> <div id="Info"> <p><strong>Keywords:</strong> <a href="/search;jsessionid=2joanp352dm0r.x-ic-live-01?option1=keywords&value1='AmpC+%26%23946%3b-lactamase'">AmpC β-lactamase</a>; <a href="/search;jsessionid=2joanp352dm0r.x-ic-live-01?option1=keywords&value1='Klebsiella+pneumonia'">Klebsiella pneumonia</a>; <a href="/search;jsessionid=2joanp352dm0r.x-ic-live-01?option1=keywords&value1='antibiotic+resistant'">antibiotic resistant</a>; <a href="/search;jsessionid=2joanp352dm0r.x-ic-live-01?option1=keywords&value1='metallo+%26%23946%3b-lactamase'">metallo β-lactamase</a> </p> <p><strong>Document Type:</strong> Research Article</p> <p><strong>Affiliations:</strong> <strong id="aff_1">1: </strong> <span id="aff_ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia _contents"> Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia </span> <strong id="aff_2">2: </strong> <span id="aff_ Department of Biology, Branch of Biotechnology, College of Science, AL-Mustansiryia, University, Baghdad, Iraq _contents"> Department of Biology, Branch of Biotechnology, College of Science, AL-Mustansiryia, University, Baghdad, Iraq </span> <strong id="aff_3">3: </strong> <span id="aff_ College of Life Science, Maulana Azad College of Arts and Science, Aurangabad, Maharashtra, India._contents"> College of Life Science, Maulana Azad College of Arts and Science, Aurangabad, Maharashtra, India.</span> </p> <p>Publication date: October 1, 2017 </p> <script type="text/javascript" > $(document).ready(function() { const MAGIC_LENGTH = 350; var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\</g, '<').replace(/\\>/g, '>').replace(/\\t/g, '   ').replace(/\\n/g, '<br />'); if (shortdescription.length > MAGIC_LENGTH) { shortdescription = "<span class='shortdescription'>" + shortdescription.substring(0, MAGIC_LENGTH - 100) + "... <a href='#'>more</a></span>"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").on("click", function(e) { e.preventDefault(); 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