Skip to main content
padlock icon - secure page this page is secure

Open Access Berberine containing quadruple therapy for initial Helicobacter pylori eradication

Download Article:
 Download
(PDF 293 kb)
 
Background:

Due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for Helicobacter pylori (H pylori) eradication. However, different results are varied greatly and the availability of bismuth was limited in some countries. We assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an alternative regimen for H pylori eradication.
Methods:

In a randomized, open-label, non-inferiority, phase IV trial between November 25, 2014, and October 15, 2015, 612 treatment-naive patients were randomly assigned to 14-day berberine-containing (n = 308) or 14-day bismuth-containing (n = 304) quadruple therapy. The primary outcomes were eradication rates determined by the 13C urea breath test (13C-UBT) 28 days after the end of treatment. The secondary outcomes were adverse events and compliance.
Results:

The baseline demographic data including age, gender, body mass index (BMI), general condition and severity score were not statistically different in both groups. The eradication rates in bismuth and berberine groups were 86.4% (266/308) and 90.1% (274/304) in intention-to-treat (ITT) analysis (P = .149), and 89.6% (266/297) and 91.3% (273/299) in per-protocol (PP) analysis (P = .470), respectively. No statistically significant difference was found in the overall incidence of adverse events between both groups (35.7% vs 28.6%, P = .060).
Conclusions:

Both regimens achieved the recommended efficacy for H pylori eradication. The berberine-containing quadruple regimen was not inferior to bismuth-containing quadruple regimen and can be recommended as an alternative regimen for H pylori eradication in the local region.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Keywords: Helicobacter pylori; berberine; bismuth; eradication; quadruple therapy

Document Type: Research Article

Affiliations: 1: State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital 2: Department of Health Statistics, Fourth Military Medical University, Xi’an, Shaanxi Province, China.

Publication date: August 1, 2017

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more