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Chronic obstructive pulmonary disease: the impact of gender

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Purpose of review

Chronic obstructive pulmonary disease (COPD) is a widely prevalent and potentially preventable cause of death worldwide. The purpose of this review is to summarize the influence of gender on various attributes of this disease, which will help physicians provide more personalized care to COPD patients.

Recent findings

Cultural trends in smoking have morphed the epidemiology of this traditionally male disease. There is an increasing ‘disease burden’ among women with COPD as suggested by the higher prevalence and slower decline in death rates as compared with men. Biologic differences between the genders account for some, but not all of these differences. In women, distinct features need to be considered to boost success of therapeutic interventions such as smoking cessation, addressing comorbidities, and attendance to pulmonary rehabilitation.Summary

COPD in women is distinct from that in men with respect to phenotype, symptom burden, and comorbidities. Women are more predisposed to develop chronic bronchitis, have more dyspnea, and suffer more frequently from coexistent anxiety or depression. They may be more subject than men to misdiagnoses and/or underdiagnoses of COPD, often as a result of physician bias. Knowledge of these gender differences can lead to more effective tailored care of the COPD patient.
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Keywords: COPD; chronic obstructive pulmonary disease; gender; gender difference; sex

Document Type: Research Article

Affiliations: 1: Division of Pulmonary and Critical Care, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 2: Division of Primary Care, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois, USA

Publication date: March 1, 2017

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