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Long-term Hearing Preservation After Resection of Vestibular Schwannoma: A Systematic Review and Meta-analysis

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Objective:

The objective is to perform a systematic review and meta-analysis of the literature on the long-term results of hearing preservation after vestibular schwannoma resection.

Data Sources:

Ovid/Medline, PubMed, Embase, and the Cochrane library from January 1980 to January 2015.

Study Selection:

Inclusion criteria: age ≥18 years, minimum 10 patients in the treatment group, hearing preserving microsurgery, no previous radiation treatment, serviceable hearing at immediate postop follow-up, hearing outcomes reported using Gardner Robinson or the American Academy of Otolaryngology-Head and Neck Surgeons hearing grading scales, and average follow-up of 5 years. Preoperative, immediate postoperative, and last follow-up audiograms were required. Exclusion criteria included neurofibromatosis type 2 patients and surgery for salvage therapy or decompression.

Data Extraction:

Quality evaluated using Methodological Index for Non-Randomized Studies.

Data Synthesis:

Meta-analysis was performed using R v3.2.2, Metafor package v 1.9-7. Cohen's D was used to determine effect size. Ten reports had at least 5-year follow-up and used standardized hearing grading scales. The systematic review found that if hearing was preserved at Class A or B at early postop visit, the chance of preserving hearing at 5 years was excellent. Those who maintained speech discrimination score ≥ 89% at the early postoperative follow-up had better long-term hearing preservation. The meta-analysis reveals that only preoperative and postoperative pure-tone average was associated with long-term hearing preservation.Conclusion:

Long-term (>5 yr) hearing durability rates are generally very good. Most studies do not report patient and tumor characteristics, therefore precluding combining studies for meta-analysis. Only preoperative and postoperative postoperative pure-tone average was associated with long-term hearing durability.
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Keywords: Acoustic neuroma; Hearing preservation; Long-term hearing preservation; Vestibular schwannoma

Document Type: Research Article

Affiliations: 1: Department of Otolaryngology 2: Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan

Publication date: December 1, 2017

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