@article {Takeuchi:2017:1531-7129:e451,
title = "Analysis of Otologic Features of Patients With Primary Ciliary Dyskinesia",
journal = "Otology & Neurotology",
parent_itemid = "infobike://wk/mao",
publishercode ="wk",
year = "2017",
volume = "38",
number = "10",
publication date ="2017-12-01T00:00:00",
pages = "e451-e456",
itemtype = "ARTICLE",
issn = "1531-7129",
eissn = "1537-4505",
url = "https://www.ingentaconnect.com/content/wk/mao/2017/00000038/00000010/art00010",
doi = "doi:10.1097/MAO.0000000000001599",
keyword = "Eardrum, Audiometry, Secretory otitis media",
author = "Takeuchi, Kazuhiko and Kitano, Masako and Sakaida, Hiroshi and Usui, Satoko and Masuda, Sawako and Ogawa, Satoru and Ikejiri, Makoto and Nagao, Mizuho and Fujisawa, Takao and Nakatani, Kaname",
abstract = "
Objective:
To evaluate otologic features of primary ciliary dyskinesia (PCD), especially eardrum features, audiometric findings, and clinical course.
Study Design:
Retrospective patient review.
Setting:
Tertiary referral center.<sec
sec-type="subjects">Patients:
Fifteen patients (mean age, 16.9 years [range, 132 yr]; 8 males and 7 females) diagnosed with PCD at our university hospital in the last 12 years.
Intervention:
Diagnostic.
Main Outcome Measures:
Electron
microscopy of nasal cilia, gene mutation analysis, endoscopy of 30 eardrums, pure-tone audiometry, and tympanometry.Results:
All 15 patients showed ciliary ultrastructural abnormalities on electron microscopy and/or biallelic mutations in genes
associated with ciliary function or structure. All 30 eardrums examined showed certain abnormalities. Fourteen patients had otitis media with effusion or its sequelae. The remaining patient had chronic otitis media. Pure-tone audiometry revealed the mean air conduction thresholds to be 25.0
and 26.4dB in the right and left ears, respectively. In the ears with better hearing and worse hearing, the mean air conduction thresholds were 22.3 and 29.0dB respectively.Conclusion:
Otologic disease among patients with
PCD essentially comprised otitis media with effusion, and the patients eardrums showed a variety of findings. Knowledge of these otologic features may lead to the early detection of PCD.",
}